Using genetic information to predict how well a donor organ will work
Organ shortage is a major problem in transplantation. In an effort to provide transplants for the hundreds of thousands of patients who are on the waiting list worldwide, doctors are considering organs from older donors, some of whom have medical problems. Many of these transplants ultimately work well, but some do not.
The aim of our cross-cutting theme is to try and produce tests that can be performed on an organ prior to transplantation that will provide an accurate prediction of how well it will work in the long-term once it is in the recipient. These tests are based on measuring differences in the genetic code, the instruction manual for the building blocks of organs, as well as assessing the building blocks themselves. Ultimately, this information will help doctors to make better decisions about whether to use an organ, increasing the number and quality of transplant operations that are carried out.
Our research-in-action video explains more about our work: https://youtu.be/c6d5mp5zDLg