Novel approaches for assessing donor organ quality
Led by Mr Colin Wilson, our research is centered on assessing donor organ quality prior to transplantation in both the chest and abdomen. Our principal aim is to develop techniques that allow assessment of organs prior to transplantation and increase the utilisation of organs.
Theme Lead: Mr Colin Wilson
Professor Paul Corris
Professor Andy Fisher
Professor Chris Watson
Professor Mike Nicholson
Mr Gavin Pettigrew
Professor Menna Clatworthy
Dr Sarah Hosgood
Collaborations within the BTRU
We have specific collaborations with the liver, lung and kidney ex vivo perfusion teams. A number of the technologies we are utilising are designed to be used as ‘point of care’ rapid diagnosis tests to facilitate decision making between donation and transplantation.
Collaborations with industry
We are working with the company AedStem to develop an iPad app which can score livers donated for transplantation based on a photograph and a simple grayscale slide. This will be used to assess organs objectively at the time of donation to help surgeons make educated judgements about whether to use a liver for transplant.
NIHR have agreed to co-fund a specific preimplantation biopsy service across the BTRU other UK sites to assess organs prior to implantation.
Other external funding
1. Mallon DH, Riddiough GE, Summers DM, Butler AJ, Callaghan CJ, Bradbury LL, Bardsley V, Broecker V, Saeb-Parsy K, Torpey N, Bradley JA, Pettigrew GJ. (2015), Successful Transplantation of Kidneys From Elderly Circulatory Death Donors by Using Microscopic and Macroscopic Characteristics to Guide Single or Dual Implantation. Am J Transplant. 2015; 15: 2931–2939 PubMed 26108421
2. Andreasson A, Karamanou DM, Perry JD, Perry A, Özalp F, Butt T, Morley KE, Walden HR, Clark SC, Prabhu M, Corris PA, Gould K, Fisher AJ, Dark JH. The effect of ex vivo lung perfusion on microbial load in human donor lungs. J Heart Lung Transplant. 2014; 33(9): 910–916 PubMed 24631044