Publications arising from the work of the current NIHR BTRU in ODT will appear here. To view publications from the 2015-2022 NIHR BTRU in ODT, please visit the 2015-2022 Publications page.
Bahadori K, Lee CYC, Ferdinand JR, Cabantous M, Butler AJ, Rouhani FJ, Watson CJE, Clatworthy MR. Inflammatory Gene Expression in Livers Undergoing Ex Situ Normothermic Perfusion Is Attenuated by Leukocyte Removal From the Perfusate. Transplantation. 2024 Oct 1
Bos S, Hunter B, McDonald D, Merces G, Sheldon G, Pradère P, Majo J, Pulle J, Vanstapel A, Vanaudenaerde BM, Vos R, Filby AJ, Fisher AJ. High-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction. J Heart Lung Transplant. 2024 Nov 26
Brevini T, Sampaziotis F. Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration. Am J Transplant. 2025 Jan
Chilvers NJS, Gilmour J, Brown ML, Bates L, Pang CY, Pauli H, Dark J, Fisher AJ. A Split-Lung Ex Vivo Perfusion Model for Time- and Cost-Effective Evaluation of Therapeutic Interventions to the Human Donor Lung. Transpl Int. 2024 Feb 28
Dobbins JJ, Tingle SJ, Mehew J, Thompson ER, Kourounis G, McPherson S, White SA, Wilson CH. Impact of donor transaminases on liver transplant utilisation and unnecessary organ discard: national registry cohort study. Front Transplant. 2024 Sep 4
Evans A, Mawson P, Thomas H, Keen K, Watson CJ, McAuley DF, MacGowan GA, Sheerin NS, Fisher A, Shaw J, Yates H, Fallow A, Kounali D, Banks J, Stevens M, Paul R, Hodge R, Lawson E, Harvey D, Dark J. SIGNET: protocol for a multicentre, single-blind prospective, group sequential, randomised controlled trial to evaluate the benefits of a single dose of simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients. BMJ Open. 2024 Sep 18
Greenhall GHB, Rous BA, Robb ML, Brown C, Hardman G, Hilton RM, Neuberger JM, Dark JH, Johnson RJ, Forsythe JLR, Tomlinson LA, Callaghan CJ, Watson CJE. Organ Transplants From Deceased Donors With Primary Brain Tumors and Risk of Cancer Transmission. JAMA Surg. 2023 Mar 22
Ho NX, Tingle SJ, Kourounis G, Mahendran B, Bramley R, Thompson ER, Amer A, Figueiredo R, McPherson S, White S, Wilson C. Visual assessment of liver steatosis at retrieval predicts long term liver transplant outcomes in donation following circulatory death. HPB (Oxford). 2025 Jan 14
Ho NX, Tingle SJ, Malik AK, Thompson ER, Kourounis G, Amer A, Pandanaboyana S, Wilson C, White S. Donor Blood Tests do Not Predict Pancreas Graft Survival After Simultaneous Pancreas Kidney Transplantation; a National Cohort Study. Transpl Int. 2024 May 20
Jenkins R, Rimmer B, Marson L, Fisher AJ, Sharp L, Exley C. Measuring patient-reported experience of solid organ transplantation healthcare: A scoping review of condition- and transplant-specific measures. Transplant Rev (Orlando). 2024 Jul 15
Kanemaru K, Cranley J, Muraro D, Miranda AMA, Ho SY, Wilbrey-Clark A, Patrick Pett J, Polanski K, Richardson L, Litvinukova M, Kumasaka N, Qin Y, Jablonska Z, Semprich CI, Mach L, Dabrowska M, Richoz N, Bolt L, Mamanova L, Kapuge R, Barnett SN, Perera S, Talavera-López C, Mulas I, Mahbubani KT, Tuck L, Wang L, Huang MM, Prete M, Pritchard S, Dark J, Saeb-Parsy K, Patel M, Clatworthy MR, Hübner N, Chowdhury RA, Noseda M, Teichmann SA. Spatially resolved multiomics of human cardiac niches. Nature. 2023 Jul 12
Kim JJ, Curtis RMK, Reynolds B, Marks SD, Drage M, Kosmoliaptsis V, Dudley J, Williams A. The UK kidney donor risk index poorly predicts long-term transplant survival in paediatric kidney transplant recipients. Front Immunol 2023 Jun 2
Kim JJ, Fichtner A, Copley HC, Gragert L, Süsal C, Dello Strologo L, Oh J, Pape L, Weber LT, Weitz M, König J, Krupka K, Tönshoff B, Kosmoliaptsis V. Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation. Front Immunol 2023 Mar 15
Kourounis G, Elmahmudi A, Thomson B, Nandi R, Tingle S, Glover E, Thompson E, Mahendran B, Connelly C, Gibson B, Bates L, Sheerin N, Hunter J, Ugail H, Wilson C. Deep learning for automated boundary detection and segmentation in organ donation photography. Innov Surg Sci. 2024 Aug 20
Kourounis G, Elmahmudi AA, Thomson B, Hunter J, Ugail H, Wilson C. Computer image analysis with artificial intelligence: a practical introduction to convolutional neural networks for medical professionals. Postgrad Med J. 2023 Nov 20
Kourounis G, Elmahmudi AA, Thomson B, Tingle SJ, Glover EK, Mahendran B, Thompson E, Abbas SH, Al-Leswas D, Brown C, El Zawahry MAMES, Georgiades F, Knight SR, Kuzman M, Owen R, Psaltis E, Hunter J, Ugail H, Wilson C. Evaluating image quality in surgical photography: a multivariable analysis of cameras and shooting conditions. J Vis Commun Med. 2025 Feb 17
MacMillan S, Hosgood SA, Walker-Panse L, Rahfeld P, Macdonald SS, Kizhakkedathu JN, Withers SG, Nicholson ML. Enzymatic conversion of human blood group A kidneys to universal blood group O. Nat Commun. 2024 Mar 30
Malik AK, Tingle SJ, Chung N, Owen R, Mahendran B, Counter C, Sinha S, Muthasamy A, Sutherland A, Casey J, Drage M, van Dellen D, Callaghan CJ, Elker D, Manas DM, Pettigrew GJ, Wilson CH, White SA; NHSBT Pancreas Advisory Group. The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation. Am J Transplant. 2024 Feb 13
Malik AK, Tingle SJ, Varghese C, Owen R, Mahendran B, Figueiredo R, Amer AO, Currie IS, White SA, Manas DM, Wilson CH. Does Time to Asystole in Donors After Circulatory Death Impact Recipient Outcome in Liver Transplantation? Transplantation. 2024 May 21
Martin JL, Rhodes F, Upponi S, Udeaja Y, Swift L, Fear C, Webster R, Webb GJ, Allison M, Paterson A, Gaurav R, Butler AJ, Watson CJE. Localized Liver Injury During Normothermic Ex Situ Liver Perfusion Has No Impact on Short-term Liver Transplant Outcomes. Transplantation. 2024 Feb 29
Mehew JD, Hogg R, Clark S, Santhanakrishnan K, Catarino P, Mascaro J, Stock U, Dark J. Risk of prolonged ischaemic time linked to use of cardio-pulmonary bypass during implantation for lung transplantation in the United Kingdom. J Heart Lung Transplant. 2023 Apr 29
Mehta M, Hosgood S, Nicholson ML. Protocol for a single-centre randomised pilot study to assess the safety and feasibility of adding a CytoSorb filter during kidney normothermic machine perfusion to remove inflammatory and immune mediators prior to kidney transplantation. BMJ Open. 2025 Mar 29
Owen RV, Carr HJ, Counter C, Tingle SJ, Thompson ER, Manas DM, Shaw JA, Wilson CH, White SA. Multi-Centre UK Analysis of Simultaneous Pancreas and Kidney (SPK) Transplant in Recipients With Type 2 Diabetes Mellitus. Transpl Int. 2024 Feb 2
Pither T, Wang L, Bates L, Morrison M, Charlton C, Griffiths C, Macdonald J, Bigley V, Mavridou M, Barsby J, Borthwick L, Dark J, Scott W 3rd, Ali S, Fisher AJ. Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model. Transplantation 2023 May 5
Pradère P, Zajacova A, Bos S, Le Pavec J, Fisher A. Molecular monitoring of lung allograft health: is it ready for routine clinical use? Eur Respir Rev. 2023 Nov 22
Pradère P, Le Pavec J, Bos S, Pozza A, Nair A, Meachery G, Lordan J, Humbert M, Mercier O, Fadel E, Savale L, Fisher AJ. Outcomes of listing for lung and heart-lung transplantation in pulmonary hypertension: comparative experience in France and the UK. ERJ Open Res. 2024 Jan 22
Pradere P, Le Pavec J, Morisset S, Gerovasili V, Kessler R, Adlakha A, Bunel V, Santhanakrishnan K, Demant X, Roux A, Falque L, Cottin V, Parmar J, Reynaud-Gaubert M, Villeneuve T, Tissot A, Mercier O, Fisher AJ. Donor to recipient age matching in lung transplantation: A European experience. J Heart Lung Transplant. 2024 Jun 21
Priddey A, Chen-Xu MXH, Cooper DJ, MacMillan S, Meisl G, Xu CK, Hosmillo M, Goodfellow IG, Kollyfas R, Doffinger R, Bradley JR, Mohorianu II, Jones R, Knowles TPJ, Smith R, Kosmoliaptsis V. Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy. Front Immunol. 2024 Jan 8;14:1296148
Qureshi S, Elliott H, Noel A, Swift L, Fear C, Webster R, Brown NM, Gaurav R, Butler AJ, Watson CJE. Infection and Prophylaxis During Normothermic Liver Perfusion: Audit of Incidence and Pharmacokinetics of Antimicrobial Therapy. Transplantation. 2024 Jan 10
Richards JA, Gaurav R, Upponi SS, Swift L, Fear C, Webb GJ, Allison MED, Watson CJE, Butler AJ. Outcomes of livers from donation after circulatory death donors with extended agonal phase and the adjunct of normothermic regional perfusion. Br J Surg. 2023 Aug 11
Rimmer B, Jenkins R, Russell S, Craig D, Sharp L, Exley C. Assessing quality of life in solid organ transplant recipients: A systematic review of the development, content, and quality of available condition- and transplant-specific patient-reported outcome measures. Transplant Rev. 2024 Feb 13
Tingle SJ, Kourounis G, Mahendran B, Mehew J, Wilson CH. Uncertainty about how the early benefits of kidney transplant versus dialysis differ in ethnic minorities. Br J Surg. 2024 May 3
Tingle SJ, Kourounis G, Liu F, Wilson CH, Richardson R, Sandercock J. Simple tool implementing Bucher’s method for indirect treatment comparisons in meta-analyses. BMJ Evid Based Med. 2024 Jul 30
Tingle SJ, Chung NDH, Malik AK, Kourounis G, Thompson E, Glover EK, Mehew J, Philip J, Gardiner D, Pettigrew GJ, Callaghan C, Sheerin NS, Wilson CH. Donor Time to Death and Kidney Transplant Outcomes in the Setting of a 3-Hour Minimum Wait Policy. JAMA Netw Open. 2024 Nov 4
Watson CJE, MacDonald S, Bridgeman C, Brais R, Upponi SS, Foukaneli T, Swift L, Fear C, Selves L, Kosmoliaptsis V, Allison M, Hogg R, Parsy KS, Thomas W, Gaurav R, Butler AJ. D-dimer release from livers during ex situ normothermic perfusion and after in situ normothermic regional perfusion: evidence for occult fibrin burden associated with adverse transplant outcomes and cholangiopathy. Transplantation 2023 Jan 6
Watson CJE, Gaurav R, Swift L, Fear C, Allison MED, Upponi SS, Brais R, Butler AJ. Bile Chemistry During Ex Situ Normothermic Liver Perfusion Does Not Always Predict Cholangiopathy. Transplantation. 2024 Feb 27
Watson CJE, Gaurav R, Butler AJ. Current Techniques and Indications for Machine Perfusion and Regional Perfusion in Deceased Donor Liver Transplantation. J Clin Exp Hepatol. 2024 Mar-Apr
Watson CJE, Gaurav R, Swift L, Fear C, Allison MED, Upponi SS, Brais R, Butler AJ. Bile Chemistry During Ex Situ Normothermic Liver Perfusion Does Not Always Predict Cholangiopathy. Transplantation. 2024 Jun 1
